Administracja gmin wiejskich w Królestwie Polskim w latach 1815–1864

W Królestwie Polskim utrzymano istnienie gminy wiejskiej utworzonej w Księstwie Warszawskim, z tą różnicą, że na początku całkowicie zrezygnowano z wprowadzenia elementów samorządu gminnego. Nie opracowano stabilnego podziału kraju na gminy. Urząd wójta powiązano z dominium, właściciel ziemski obligatoryjnie był wójtem, ale mógł wyznaczyć zastępcę, który w jego imieniu wykonywał te obowiązki. Przez dziesięciolecia istnienia Królestwa liczba i wielkość gmin notorycznie się zmieniały. Reformy, do których doszło w tym zakresie w 1859, a szczególnie w 1864 roku, wymuszone zostały m.in. przez przemiany cywilizacyjne, rozwój biurokracji oraz politykę. Ostatecznie dopiero w 1859 roku rozpoczęto proces ograniczania rozdrobnienia wsi na małe gminy, a w 1864 roku głęboko zreformowano wieś Królestwa, wprowadzono samorząd wiejski, który był jedynym samorządem terenowym w Królestwie Polskim do końca jego istnienia

Minichromosome maintenance (MCM) and AgNOR proteins expression in desmoid tumours: a tissue microarray analysis.

In the present study, nuclear proliferative proteins: MCM2, MCM5, MCM7, Ki-67 and AgNORs expression was assessed in paraffin sections from sporadic desmoid tumours using a tissue microarray (TMA)-based immuno- and histochemistry, respectively. Nuclear expression of MCM7, where the percentage of positive cells was 0.87% (Âą 1.64) (range 0-5%), was found in 4/20 (20.0%) cases. In 32/32 (100%) of the examined desmoid cases no expression of nuclear proteins MCM2 and MCM5 was detected. Nuclear expression of Ki-67 was observed in 4/21 (19%) cases. Paraffin sections from 30 cases of desmoid tumours were silver-stained to visualize AgNORs. The following AgNOR parameters were calculated: mean AgNOR number per nucleus (N), mean AgNOR area per nucleus, mean AgNOR dot area per nucleus (A), and mean AgNOR content (C = N/A). In the investigated group the mean values of AgNOR parameters were the following number: 4.34 (Âą 0.11); area: 0.74 Îźm2 (Âą 0.19); dot area: 0.18 m2 (Âą 0.01), and AgNOR content: 23.73 (Âą 1.85). The mean AgNOR number per nucleus and mean AgNOR content in desmoid tumours were statistically significantly higher as compared to the controls (tonsil tissue) (

Guidelines from the Polish Surgical Society and Polish Society of Oncological Surgery Concerning Quality Assurance for Centres Performing Cytoreductive Procedures and HIPEC Procedures in the Treatment of Primary and Secondary Peritoneal Tumours

Surgical treatment of patients with peritoneal metastases in combination with Hyperthermic intraperitoneal Chemotherapy (HIPEC) and systemic treatments is applied with increasing frequency and, with correct patient qualification, allows for obtaining 5-year survival at a level of 32–52%. The conditions necessary for positive results of such treatment include the high experience of a given centre, its appropriate infrastructure, and appropriate patient qualification for the procedure. As a result of the debate connected with the need to evaluate treatment quality and results, at the request of the Peritoneal Cancer Section of the Polish Society of Oncological Surgery, the conditions for quality assurance were worked out and a Quality Assurance Commission was set up for the centres performing cytoreductive procedures and HIPEC procedures in the treatment of primary and secondary peritoneal tumours

Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer—a case control study

XRCC2 and XRCC3 proteins are structurally and functionally related to RAD51 which play an important role in the homologous recombination, the process frequently involved in cancer transformation. In our previous work we show that the 135G>C polymorphism (rs1801320) of the RAD51 gene can modify the effect of the Thr241Met polymorphism (rs861539) of the XRCC3 gene. We tested the association between the 135G>C polymorphism of the RAD51 gene, the Thr241Met polymorphism of the XRCC3 gene and the Arg188His polymorphism (rs3218536) of the XRCC2 gene and colorectal cancer risk and clinicopathological parameters. Polymorphisms were evaluated by restriction fragment length polymorphism polymerase chain reaction (RFLP-PCR) in 100 patients with invasive adenocarcinoma of the colon and in 100 sex, age and ethnicity matched cancer–free controls. We stratified the patients by genotypes, tumour Duke’s and TNM stage and calculated the linkage of each genotype with each stratum. Carriers of Arg188Arg/Me241tMet, His188His/Thr241Thr and His188His/G135G genotypes had an increased risk of colorectal cancer occurrence (OR 5.70, 95% CI 1.10–29.5; OR 12.4, 95% CI 1.63–94.9; OR 5.88, 95% CI 1.21–28.5, respectively). The C135C genotype decreased the risk of colorectal cancer singly (OR 0.06, 95% CI 0.02–0.22) as well as in combination with other two polymorphisms. TNM and Duke’s staging were not related to any of these polymorphisms. Our results suggest that the 135G>C polymorphism of the RAD51 gene can be an independent marker of colorectal cancer risk. The Thr241Met polymorphism of the XRCC3 gene and the Arg188His polymorphism of the XRCC2 gene can modify the risk of colorectal cancer

Sulfit-Cellulose I. & M. Cassirer’s Factory in Wloclawek in the years 1898–1920

In 1898, the two German entrepreneurs of the Jewish descent, Max and Izydor Cassirer, founded a company the aim of which was to build a sulfate cellulose factory in Wloclawek. Within the same year they purchased first properties and started the building process that was completed in 1899. From the very beginning the factory in Wloclawek was considered to be the greatest manufacturing enterprise in town, was the only cellulose factory in Kingdom of Poland (until 1914), and one of a few in the whole Russian Empire. The opening of the factory had an impact on the demographic and spatial development of the town and forced changes in the branch structure of the Wloclawek industry. One of the outcomes of the manufacturing of the raw matrial that is central to paper production was opening of the two paper mills in Wloclawek. The establishment of the cellulose factory had also social effects in that it grounded the image of the town as the labour centre. The local society faced then for the fist time with environmental pollution caused by the factory on such a large scale. The company remained in the German hands until the restoration of Poland’s sovereignty, then, in 1920, it was sold, and eventually joined a well-known Polish pulp and paper concern

Administrative divisions of Poland, 1944–1998. The study on Polish territories in the 19th and the 20th centuries

In the 20th century many territorial reforms were introduced. The reforms in 1918 were problematic due to the re-creation of Polish independent state after more than a century of partitions by Austria-Hungary, the German, and the Russian Empires. After 1945 the estab-lishment of new administrative units was still a difficult issue since again the government had to take new Polish borders into consideration before making a decision. The adminis-trative changes between 1945 and 1946 were soon followed by another set of reforms. The major ones were introduced in 1950, early 1970s and 1998. There were also many reforms between the mentioned periods, however, those changes dealt with single cities, villages and other small administrative units. Quite frequently, especially between 1952 and 1989 (The Polish People's Republic) the reforms served political rather than social needs. The present administrative division has been valid since 1999

Genetic Variations of the CTNNA1 And The CTNNB1 Genes in Sporadic Colorectal Cancer in Polish Population

Experimental as well as clinical observations have demonstrated that the E-cadherin/catenin complex is a powerful inhibitor of invasion. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The aim of the study was to determine the CTNNA1 and the CTNNB1 mutations and its relationship to clinical and pathological features of sporadic colorectal cancer (CRC) in Polish patients. Material and methods. Paired tumor and normal tissue samples from 110 sporadic CRC patients undergoing resective surgery were prospectively studied for the alpha catenin (CTNNA1) gene and beta catenin (CTNNB1)gene mutations by PCR/single strand conformation polymorphism (SSCP). Results. The CTNNA1 gene alteration in exon 7 were detected in 4 samples and in exon 3 of CTNNB1 gene were found in 3 samples. There was a trend at the limit of statistical significance associating younger age at diagnosis (<50) with CTNNA1 and the CTNNB1 mutations. The mutation of CTNNB1 seemed to occur more frequently in the proximal colon than distal. The CRC patients with CTNNA1 mutation had a significantly increased lymph node metastasis. On the other hand, there was no correlation between mutations and the other clinical variables (e.g. sex, grade and depth of invasion). Conclusion. Although we found a low frequency of mutations in the CTNNA1 and the CTNNB1 genes, but the analysis the relationship with clinical and pathological features of CRC patients may indicated an association of these mutations with the risk and progression of CRC

English

Mortality crises are periods of unusually high mortality resulted from a combination of epidemic episodes, climatic phenomena, historical events and sociopolitical factors. The most pronounced setback in the methodology applied to analyse mortality rates of historical populations is the inability to establish their size.Reference publications do not provide unambiguous measures of the intensity and scale of mortality crisis periods. This problem was approached with the use of the Standardised Demographic Dynamics Rate (SDDR) whose value provides information about the condition of a population, disregarding the size of the group. Demographic crises were indicated and identified among the population living in the 19th century in central Poland in the rural parish. The analysis was based on data obtained from parish registers, made use of the measure expressing the ratio of the number of births to the number of deaths, without using the size of the group.Results obtained from the analysis of data were set against the information about events causing a sudden growth in mortality derived from the widely-accessible literature. Value of the Standardised Demographic Dynamics Rate (SDDR) provides information aboutthe condition of a population, disregarding the size of the group. Nevertheless, only by combining the statistically obtained data with the information derived from written records it is possible to attempt to answer the question of the possible root cause of a demographic crisis